Book it from Houston to Santo Domingo on JetBlue from $356*.

Best flight offers from Houston to Santo Domingo

Try updating your route (origin and/or destination) or interact with individual dates below in order to find offers.
Displaying fares for April-2025
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Weather in Santo Domingo? We’ve got you covered.

lunes

nubes

60°F

Abr 7

martes

lluvia ligera

50°F

Abr 8

miércoles

rain and snow

50°F

Abr 9

jueves

nubes

58°F

Abr 10

viernes

lluvia ligera

62°F

Abr 11

sábado

rain and snow

54°F

Abr 12

domingo

nieve

35°F

Abr 13

Powered by: OpenWeatherMap.org

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When you book direct on jetblue.com or the JetBlue app, you’re guaranteed to get our best fares. Plus, it’s easier to manage your booking if your travel plans change (we’ve got your back when the unexpected happens). Whether you’re just looking for a cheap flight or a vacation package that bundles flights with hotel, cruise, car &/or activities, booking directly with us gives you deals and discounts you won’t find anywhere else, more flexibility, and you’ll earn bonus TrueBlue points toward future award travel, as well as tiles toward valuable Perks You Pick®.

You can use TrueBlue points to book on jetblue.com or the JetBlue app. And if you’re short on points (or cash), you can also use your TrueBlue points (as few as 500 points!) toward a Cash + Points booking. It’s like getting a discount.